STAT1 Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-32977
Zusätzliche Namen:: CANDF7,DKFZp686B04100,IMD31A,IMD31B,IMD31C,ISGF 3,ISGF-3,OTTHUMP00000163552,OTTHUMP00000165046,OTTHUMP00000165047,OTTHUMP00000205845,Signal tr,Signal transducer and activator of transcription 1 91kD,Signal transducer and activator of transcription 1 91kDa
Anwendung:: IHC, WB, IHC-P, IF
Konzentration:: 1 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
Immunogen:: Synthesized peptide derived from human Stat1 around the non-phosphorylation site of Ser727.
Uniprot:: P42224
Synonyme:: CANDF7;IMD31A;IMD31B;IMD31C;ISGF-3;signal transducer and activator of transcription 1-alpha/beta;signal transducer and activator of transcription 1, 91kD;signal transducer and activator of transcription 1, 91kDa;STAT91;transcription factor ISGF-3 components p91/p84
Weitere Details:: Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Versandbedingungen:: Blue Ice