E-AB-32546
PERK Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-32546
- Zusätzliche Namen:
- DKFZp781H1925,E2AK3,EC 2.7.11.1,Eif2ak3,Eukaryotic translation initiation factor 2 alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3,HRI,Heme regulated EIF2 alpha kinase,HsPEK,Pancreatic eIF2 alpha kinase,Pancreatic eIF2-alpha kinas
- Anwendung:
- IHC, WB, IHC-P, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human PERK
- Uniprot:
- Q9NZJ5
- Synonyme:
- eukaryotic translation initiation factor 2-alpha kinase 3;pancreatic EIF2-alpha kinase;PEK;PERK;PRKR-like endoplasmic reticulum kinase;truncated eukaryotic translation initiation factor 2 alpha kinase 3;WRS
- Weitere Details:
- Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1.
- Versandbedingungen:
- Blue Ice