E-AB-32152
N/H/K-Ras Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-32152
- Zusätzliche Namen:
- GTPase HRas,GTPase KRas,GTPase NRas,H-Ras-1,HRAS,HRAS1,Ha-Ras,K-Ras 2,KRAS,KRAS2,Ki-Ras,NRAS,RASK2,Transforming protein N-Ras,Transforming protein p21,c-H-ras,c-K-ras,c-Ki-ras,p21ras
- Anwendung:
- IHC, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human N/H/K-Ras
- Uniprot:
- P01111, P01112, P01116
- Synonyme:
- 'C-K-RAS;ALPS4;C-BAS/HAS;C-H-RAS;C-HA-RAS1;c-has/bas p21 protein;C-K-RAS;c-Ki-ras;c-Ki-ras2;c-Kirsten-ras protein;cellular c-Ki-ras2 proto-oncogene;cellular transforming proto-oncogene;CFC2;CMNS;CTLO;GTP- and GDP-binding peptide B;GTPase HRas;GTPase KRas;GTPase NRas;H-Ras-1;H-RASIDX;Ha-Ras;Ha-Ras1 proto-oncoprotein;HAMSV;Harvey rat sarcoma viral oncogene homolog;Harvey rat sarcoma viral oncoprotein;HRAS1;K-Ras;K-Ras 2;K-ras p21 protein;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;KI-RAS;Kirsten rat sarcoma viral oncogene homolog;Kirsten rat sarcoma viral proto-oncogene;KRAS1;KRAS2;N-ras;N-ras protein part 4;NCMS;neuroblastoma RAS viral (v-ras) oncogene homolog;neuroblastoma RAS viral oncogene homolog;NRAS1;NS;NS3;NS6;OES;oncogene KRAS2;p19 H-RasIDX protein;p21ras;PR310 c-K-ras oncogene;RALD;Ras family small GTP binding protein H-Ras;RASH1;RASK2;transformation gene: oncogene HAMSV;transforming protein N-Ras;transforming protein p21;v-Ha-ras Harvey rat sarcoma viral oncogene homolog;v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog;v-ras neuroblastoma RAS viral oncogene homolog
- Weitere Details:
- NRAS an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. KRAS, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
- Versandbedingungen:
- Blue Ice