E-AB-30460
Pan-Akt Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-30460
- Zusätzliche Namen:
- AKT1,AKT2,PKB,PKB alpha,Protein kinase Akt-2,Protein kinase B,Protein kinase B alpha,Proto-oncogene c-Akt,RAC,RAC-PK-alpha,RAC-alpha serine/threonine-protein kinase,RAC-beta serine/threonine-protein kinase
- Anwendung:
- IHC, WB, IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthesized peptide derived from human Pan-Akt around the non-phosphorylation site of Thr308.
- Uniprot:
- P31749, P31751, Q9Y243
- Synonyme:
- AKT;AKT1m;HIHGHH;MPPH;MPPH2;murine thymoma viral (v-akt) homolog-2;PKB;PKB alpha;PKB beta;PKB gamma;PKB-ALPHA;PKB-GAMMA;PKBB;PKBBETA;PKBG;PRKBA;PRKBB;PRKBG;protein kinase Akt-2;Protein kinase Akt-3;Protein kinase B;protein kinase B alpha;protein kinase B beta;Protein kinase B gamma;proto-oncogene c-Akt;putative v-akt murine thymoma viral oncoprotein 2;RAC;rac protein kinase alpha;rac protein kinase beta;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-BETA;RAC-beta serine/threonine-protein kinase;RAC-gamma;RAC-gamma serine/threonine protein kinase;RAC-gamma serine/threonine-protein kinase;RAC-PK-alpha;RAC-PK-beta;RAC-PK-gamma;serine-threonine protein kinase;STK-2;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene homolog 2;v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma);v-akt murine thymoma viral oncogene-like protein 1
- Weitere Details:
- Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
- Versandbedingungen:
- Blue Ice