E-AB-22207
SGK1 Monoclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-22207
- Zusätzliche Namen:
- OTTHUMP00000017247,Serine/threonine protein kinase SGK,Serine/threonine protein kinase Sgk1,Serine/threonine-protein kinase Sgk1,Serum and glucocorticoid regulated kinase,Serum/,Serum/glucocorticoid regulated kinase,Serum/glucocorticoid regulated kinase 1
- Anwendung:
- IHC, IHC-P
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol.
- Immunogen:
- Synthetic Peptide of SGK1
- Klon:
- 4D12
- Uniprot:
- O00141
- Synonyme:
- serine/threonine protein kinase SGK;serine/threonine-protein kinase Sgk1;Serum/glucocorticoid-regulated kinase 1;SGK;Sgk1 variant i3
- Weitere Details:
- Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
- Versandbedingungen:
- Blue Ice