E-AB-19691
CEND1 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-19691
- Zusätzliche Namen:
- BM88 ,BM88 antigen,Cell cycle exit and neuronal differentiation 1 ,Cell cycle exit and neuronal differentiation protein 1,FLJ90066,MGC34326
- Anwendung:
- IHC, WB
- Konzentration:
- 0.9 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CEND1
- Uniprot:
- Q8N111
- Synonyme:
- BM88;BM88 antigen;cell cycle exit and neuronal differentiation protein 1
- Weitere Details:
- BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.
- Versandbedingungen:
- Blue Ice