E-AB-19326
HIPK3 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-19326
- Zusätzliche Namen:
- ANPK,Androgen receptor interacting nuclear protein kinase,Androgen receptor-interacting nuclear protein kinase,DYRK6,FIST,FIST3,Fas interacting serine/threonine protein kinase,Fas-interacting serine/threonine-protein kinase,HIPK3,Hipk3,homeodomain interac
- Anwendung:
- IHC
- Konzentration:
- 0.6 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human HIPK3
- Uniprot:
- Q9H422
- Synonyme:
- androgen receptor-interacting nuclear protein kinase;ANPK;DYRK6;fas-interacting serine/threonine-protein kinase;FIST;FIST3;homeodomain-interacting protein kinase 3;homolog of protein kinase YAK1;PKY;YAK1
- Weitere Details:
- Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
- Versandbedingungen:
- Blue Ice