SPACA1 Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-19214
Zusätzliche Namen:: SACA1,SAMP32,SPACA1,Sperm acrosomal membrane-associated protein 32,Sperm acrosome membrane-associated protein 1
Anwendung:: IHC
Konzentration:: 0.84 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Fusion protein of human SPACA1
Uniprot:: Q9HBV2
Synonyme:: SAMP32;sperm acrosomal membrane-associated protein 32;sperm acrosome membrane-associated protein 1
Weitere Details:: The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively.