RIC8A Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-19028
Zusätzliche Namen:: MGC104517,MGC131931,MGC148073,MGC148074,Protein Ric-8A,RIC8,RIC8A,Synembryn-A,resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
Anwendung:: IHC
Konzentration:: 0.96 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Fusion protein of human RIC8A
Uniprot:: Q9NPQ8
Synonyme:: Protein Ric-8A;resistance to inhibitors of cholinesterase 8 homolog A;RIC8;synembryn-A
Weitere Details:: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.