E-AB-18867
RFX6 Polyclonal Antibody
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£106.20
War £118.00
- SKU:
- E-AB-18867
- Zusätzliche Namen:
- 6,DNA binding protein RFX6 ,RFX6,RFX6 regulatory factor X,Regulatory factor X domain containing protein 1
- Anwendung:
- IHC
- Konzentration:
- 0.96 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human RFX6
- Uniprot:
- Q8HWS3
- Synonyme:
- dJ955L16.1;DNA-binding protein RFX6;MTCHRS;MTFS;Regulatory factor X 6;regulatory factor X domain-containing protein 1;regulatory factor X, 6;RFXDC1
- Weitere Details:
- The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis.
- Versandbedingungen:
- Blue Ice