E-AB-18829
POLH Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-18829
- Zusätzliche Namen:
- DNA polymerase eta,FLJ16395,FLJ21978,POLH,Polh,RAD30,RAD30 homolog A,RAD30A,XP V,XPV,Xeroderma pigmentosum variant type protein,polymerase DNA directed eta
- Anwendung:
- IHC
- Konzentration:
- 1.08 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human POLH
- Uniprot:
- Q9Y253
- Synonyme:
- DNA polymerase eta;polymerase (DNA directed), eta;polymerase (DNA) eta;RAD30;RAD30 homolog A;RAD30A;xeroderma pigmentosum variant type protein;XP-V;XPV
- Weitere Details:
- This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
- Versandbedingungen:
- Blue Ice