E-AB-18773
RNF111 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-18773
- Zusätzliche Namen:
- ARK,Arkadia,DKFZp313E0731,DKFZp686H1966,DKFZp761D081,E3 ubiquitin protein ligase Arkadia,E3 ubiquitin-protein ligase Arkadia,FLJ38008,RING finger protein 111,RN111,RNF 111,RNF111
- Anwendung:
- IHC
- Konzentration:
- 0.84 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human RNF111
- Uniprot:
- Q6ZNA4
- Synonyme:
- ARK;Arkadia;E3 ubiquitin-protein ligase Arkadia;hRNF111;RING finger protein 111;RING-type E3 ubiquitin transferase Arkadia
- Weitere Details:
- The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase.This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription.As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
- Versandbedingungen:
- Blue Ice