C8orf4 Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-18766
Zusätzliche Namen:: C8orf4,CH004,Chromosome 8 open reading frame 4,Human thyroid cancer 1,MGC22806,TC-1,TC1,Thyroid cancer protein 1,Uncharacterized protein C8orf4
Anwendung:: IHC
Konzentration:: 0.96 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Fusion protein of human C8orf4
Uniprot:: Q9NR00
Synonyme:: C8orf4;human thyroid cancer 1;protein C8orf4;TC-1;TC1;thyroid cancer protein 1;transcriptional and immune response regulator
Weitere Details:: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.