E-AB-18713
NARF Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-18713
- Zusätzliche Namen:
- DKFZp434G0420,FLJ10067,GC17P078009,IOP2,Iron only hydrogenase like protein 2,Nuclear prelamin A recognition factor,Prenyl dependent prelamin A binding protein
- Anwendung:
- IHC
- Konzentration:
- 1.56 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Fusion protein of human NARF
- Uniprot:
- Q9UHQ1
- Synonyme:
- IOP2;iron-only hydrogenase-like protein 2;nuclear prelamin A recognition factor;prenyl-dependent prelamin A binding protein
- Weitere Details:
- Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends.Prenylation was initially believed to be important only for membrane attachment.However, another role for prenylation appears to be its importance in protein-protein interactions.The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins.Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif.This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A.The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain.It may be a component of a prelamin A endoprotease complex.The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina.It shares limited sequence similarity with iron-only bacterial hydrogenases.Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.
- Versandbedingungen:
- Blue Ice