E-AB-17864
CCL5 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-17864
- Zusätzliche Namen:
- Beta chemokine RANTES,Beta chemokine RANTES precursor,C C motif chemokine 5,CCL 5,CCL5,Chemokine (C C motif) ligand 5,Chemokine CC Motif Ligand 5,D17S136E,EoCP,Eosinophil chemotactic cytokine,MGC17164,RANTES(4-68),Regulated upon activation normally T
- Anwendung:
- IHC
- Konzentration:
- 2 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CCL5
- Uniprot:
- P13501
- Synonyme:
- beta-chemokine RANTES;C-C motif chemokine 5;chemokine (C-C motif) ligand 5;D17S136E;eoCP;eosinophil chemotactic cytokine;RANTES;regulated upon activation, normally T-expressed, and presumably secreted;SCYA5;SIS-delta;SISd;small inducible cytokine subfamily A (Cys-Cys), member 5;Small-inducible cytokine A5;T cell-specific protein P228;T-cell specific protein p288;T-cell-specific protein RANTES;TCP228
- Weitere Details:
- This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
- Versandbedingungen:
- Blue Ice