E-AB-16415
ESPL1 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-16415
- Zusätzliche Namen:
- Caspase like protein ESPL1,Caspase-like protein ESPL1,ESP 1,ESP1,ESPL 1,ESPL1,Espl1,Extra spindle poles like 1,Extra spindle poles like 1 protein,Extra spindle poles-like 1 protein,FLJ46492,KIAA0165,S,Separase,Separin,Similar to fission yeast cut1and gene
- Anwendung:
- IHC
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human ESPL1
- Uniprot:
- Q14674
- Synonyme:
- caspase-like protein ESPL1;ESP1;extra spindle pole bodies 1, separase;extra spindle pole bodies homolog 1;extra spindle poles like 1;extra spindle poles-like 1 protein;SEPA;Separase;separin;separin, cysteine protease
- Weitere Details:
- Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
- Versandbedingungen:
- Blue Ice