E-AB-16404
EMP2 Polyclonal Antibody
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£106.20
War £118.00
- SKU:
- E-AB-16404
- Zusätzliche Namen:
- EMP 2,EMP-2,EMP2,Epithelial membrane protein 2,Protein XMP
- Anwendung:
- IHC
- Konzentration:
- 0.8 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human EMP2
- Uniprot:
- P54851
- Synonyme:
- epithelial membrane protein 2;Protein XMP;XMP
- Weitere Details:
- EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.
- Versandbedingungen:
- Blue Ice