E-AB-16173
NUAK1 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-16173
- Zusätzliche Namen:
- AMP activated protein kinase family member 5,AMPK related protein kinase 5,AMPK-related protein kinase 5,NUAK family SNF1 like kinase,NUAK family SNF1-like kinase 1,NUAK1,Nuak1,Omphalocele kinase 1,Probable serine/threonine protein kinase KIAA0537
- Anwendung:
- IHC
- Konzentration:
- 1.4 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human NUAK1
- Uniprot:
- O60285
- Synonyme:
- AMP-activated protein kinase family member 5;AMPK-related protein kinase 5;ARK5;NUAK family SNF1-like kinase 1;NUAK family, SNF1-like kinase, 1;omphalocele kinase 1
- Weitere Details:
- NUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression.Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53.Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability.Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex.Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1.
- Versandbedingungen:
- Blue Ice