E-AB-15932
DCC Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-15932
- Zusätzliche Namen:
- CRC 18,CRC18,CRCR 1,CRCR1,Colorectal cancer related chromosome sequence 18,Colorectal cancer suppressor,DCC,Deleted in colorectal cancer protein,Deleted in colorectal carcinoma,Immunoglobulin superfamily DCC subclass member 1,Netrin receptor DCC,Tumor
- Anwendung:
- IHC
- Konzentration:
- 0.7 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human DCC
- Uniprot:
- P43146
- Synonyme:
- colorectal cancer suppressor;CRC18;CRCR1;deleted in colorectal carcinoma;HGPPS2;IGDCC1;immunoglobulin superfamily DCC subclass member 1;MRMV1;netrin receptor DCC;NTN1R1;putative colorectal tumor suppressor;tumor suppressor protein DCC
- Weitere Details:
- This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
- Versandbedingungen:
- Blue Ice