E-AB-15735
JNK2 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-15735
- Zusätzliche Namen:
- C Jun N terminal kinase 2,JNK 55,JNK-55,JNK2,JNK2 alpha,JNK2 beta,JNK2A,JNK2B,JNK2BETA,JNK2alpha,Jun kinase,MAP kinase 9,MAPK 9,MK09,Mapk9,Mitogen activated protein kinase 9,Mitogen-activated protein kinase 9,P54a,c Jun kinase 2,c-Jun N-terminal kinase 2
- Anwendung:
- IHC, WB
- Konzentration:
- 0.4 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human MAPK9
- Uniprot:
- P45984
- Synonyme:
- c-Jun kinase 2;c-Jun N-terminal kinase 2;JNK-55;JNK2;JNK2A;JNK2ALPHA;JNK2B;JNK2BETA;Jun kinase;MAP kinase 9;MAPK 9;mitogen-activated protein kinase 9;p54a;p54aSAPK;PRKM9;SAPK;SAPK1a;stress-activated protein kinase 1a;stress-activated protein kinase JNK2
- Weitere Details:
- Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells.JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
- Versandbedingungen:
- Blue Ice