E-AB-15118
p53RFP Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-15118
- Zusätzliche Namen:
- E3 ubiquitin protein ligase RNF144B,E3 ubiquitin-protein ligase RNF144B,IBR domain containing 2,IBR domain containing protein 2,IBR domain-containing protein 2,IBRDC 2,IBRDC2,KIAA0161,MGC71786,OTTHUMP000000,OTTHUMP00000016079,OTTHUMP00000016080,bA528A10.3
- Anwendung:
- IHC, WB
- Konzentration:
- 0.4 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human RNF144B
- Uniprot:
- Q7Z419
- Synonyme:
- bA528A10.3;E3 ubiquitin-protein ligase RNF144B;IBR domain containing 2;IBR domain-containing protein 2;IBRDC2;p53-inducible RING finger protein;p53RFP;PIR2;RING finger protein 144B
- Weitere Details:
- p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
- Versandbedingungen:
- Blue Ice