IPO7 Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-13336
Zusätzliche Namen:: FLJ14581,IPO 7,IPO7,Imp 7,Imp7,Importin-7,Importin7,MGC138673,RANBP 7,Ran binding protein 7,Ran-binding protein 7,RanBP7
Anwendung:: IHC, WB
Konzentration:: 0.5 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Synthetic peptide of human IPO7
Uniprot:: O95373
Synonyme:: Imp7;importin-7;RAN-binding protein 7;RANBP7
Weitere Details:: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins.