E-AB-13311
HSD11B2 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-13311
- Zusätzliche Namen:
- 11 DH2,11 beta HSD2,11 beta hydroxysteroid dehydrogenase type 2,11-DH2,11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,AME,AME1,Corticosteroid 11 beta dehydrogenase isozyme 2,Corticosteroid 11-beta-dehydrogenase isozyme 2,DHI2,HSD11B2,HSD11K,HSD2
- Anwendung:
- IHC
- Konzentration:
- 0.6 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human HSD11B2
- Uniprot:
- P80365
- Synonyme:
- -HSD11 type II;11-beta-HSD type II;11-beta-HSD2;11-beta-hydroxysteroid dehydrogenase type 2;11-beta-hydroxysteroid dehydrogenase type II;11-DH2;11-HSD type II;AME;AME1;corticosteroid 11-beta-dehydrogenase isozyme 2;HSD11K;HSD2;NAD-dependent 11-beta-hydroxysteroid dehydrogenase;SDR9C3;short chain dehydrogenase/reductase family 9C member 3
- Weitere Details:
- There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone.The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities.The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity.In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.
- Versandbedingungen:
- Blue Ice