E-AB-12926
FZD6 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-12926
- Zusätzliche Namen:
- FZD 6,FZD6,Frizzled 6 seven transmembrane spanning receptor,Frizzled drosophila homolog of 6,Frizzled family receptor 6,Frizzled homolog 6,Frizzled homolog 6 (Drosophila),Frizzled-6,Frizzled6,Fz 6,Fz-6,Fz6,Fzd6,Hfz 6,NDNC10,hFz6
- Anwendung:
- IHC
- Konzentration:
- 0.2 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human FZD6
- Uniprot:
- O60353
- Synonyme:
- frizzled 6, seven transmembrane spanning receptor;frizzled family receptor 6;frizzled homolog 6;frizzled-6;FZ-6;FZ6;HFZ6;NDNC1;NDNC10;seven transmembrane helix receptor
- Weitere Details:
- This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
- Versandbedingungen:
- Blue Ice