E-AB-12625
PRMT5 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-12625
- Zusätzliche Namen:
- 72 kDa ICln binding protein,72 kDa ICln-binding protein,ANM5,HMT1 hnRNP methyltransferase like 5,HOMOLOG OF,HRMT1L5,Histone synthetic lethal 7,Histone-arginine N-methyltransferase PRMT5,IBP72,JBP 1,JBP1,Jak-binding protein 1,S. cerevisiae,SKB1,homolog of
- Anwendung:
- WB
- Konzentration:
- 0.3 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human PRMT5
- Uniprot:
- O14744
- Synonyme:
- 72 kDa ICln-binding protein;histone-arginine N-methyltransferase PRMT5;HMT1 hnRNP methyltransferase-like 5;HRMT1L5;HSL7;IBP72;jak-binding protein 1;JBP1;protein arginine N-methyltransferase 5;shk1 kinase-binding protein 1 homolog;SKB1;SKB1 homolog;SKB1Hs
- Weitere Details:
- Protein arginine methyltransferase 5 has been shown to interact with WD repeat-containing protein 77, CLNS1A, Janus kinase 2, SNRPD3 and SUPT5H.Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3), such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation.
- Versandbedingungen:
- Blue Ice