E-AB-11313
HSP40-4 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-11313
- Zusätzliche Namen:
- DJ 2,DJ2,DNAJ2,DNJA1,DjA1,DnaJ (Hsp40) homolog,DnaJ homolog subfamily A member 1,DnaJ protein homolog 2,Dnaja1,HDJ-2,HDJ2,HSDJ,HSJ-2,HSJ2,HSPF4,Heat shock 40 kDa protein 4,Heat shock protein J2,Hum,hDJ 2,heat shock protein DNAJ like 2,member 1,subfamily A
- Anwendung:
- IHC, WB
- Konzentration:
- 0.5 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human DNAJA1
- Uniprot:
- P31689
- Synonyme:
- DJ-2;DjA1;DnaJ (Hsp40) homolog, subfamily A, member 1;dnaJ homolog subfamily A member 1;dnaJ protein homolog 2;hDJ-2;HDJ2;heat shock 40 kDa protein 4;heat shock protein J2;heat shock protein, DNAJ-like 2;HSDJ;HSJ-2;HSJ2;HSPF4;human DnaJ protein 2;NEDD7;neural precursor cell expressed, developmentally down-regulated 7
- Weitere Details:
- DnaJ-like proteins interact with HSP 70 molecular chaperones and function to facilitate protein folding and mitochondrial protein import. HSP 40-4, also known as HDJ2, is the human DnaJ homolog that functions as a co-chaperone with a cysteine-rich zinc finger domain. The cellular redox enzyme thioredoxin interacts with HSP 40-4, and oxidation and reduction reversibly regulate HSP 40-4 function in response to the changing redox states of the cell. The zinc finger domain of HSP 40-4 may act as a redox sensor of chaperone-mediated protein-folding machinery, since HSP 40-4 inactivation leads to the oxidation of cysteine thiols and a simultaneous release of coordinated zinc. Loss of the HSP 40-4 protein may be linked to severe defects in spermatogenesis that involve aberrant androgen signaling.
- Versandbedingungen:
- Blue Ice