E-AB-10998
VWA5A Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-10998
- Zusätzliche Namen:
- BCSC-1,BCSC1,LOH11CR2A
- Anwendung:
- IHC
- Konzentration:
- 0.9 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human VWA5A
- Uniprot:
- O00534
- Synonyme:
- BCSC-1;BCSC1;breast cancer suppressor candidate 1;LOH11CR2A;loss of heterozygosity 11 chromosomal region 2 gene A protein;loss of heterozygosity, 11, chromosomal region 2, gene A;ortholog of mouse AW551984;von Willebrand factor A domain-containing protein 5A
- Weitere Details:
- VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A.
- Versandbedingungen:
- Blue Ice