E-AB-10571
PTCH1 Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-10571
- Zusätzliche Namen:
- BCNS,HPE7,NBCCS,PTC,PTC1,PTCH,PTCH11
- Anwendung:
- IHC, WB
- Konzentration:
- 0.5 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human PTCH1
- Uniprot:
- Q13635
- Synonyme:
- BCNS;NBCCS;protein patched homolog 1;PTC;PTC1;PTCH
- Weitere Details:
- This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
- Versandbedingungen:
- Blue Ice