CDKN2AIP Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-10510
Zusätzliche Namen:: CARF,CDKN2A interacting protein,CDKN2A-interacting protein,Calcium response factor,Cdkn2aip,Collaborator of ARF,FLJ20036,collaborates/cooperates with ARF (alternate reading frame) protein
Anwendung:: IHC
Konzentration:: 0.3 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant protein of human CDKN2AIP
Uniprot:: Q9NXV6
Synonyme:: CARF;CDKN2A-interacting protein;collaborates/cooperates with ARF (alternate reading frame) protein;collaborator of ARF
Weitere Details:: CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.