E-AB-10378
Crystallin-alpha C Polyclonal Antibody
Größe
£106.20
War £118.00
- SKU:
- E-AB-10378
- Zusätzliche Namen:
- Alpha crystallin C chain,Alpha-crystallin C chain,CMT2L,CRYAC,Charcot Marie Tooth disease axonal type 2L,Charcot Marie Tooth disease spinal,DHMN 2,DHMN2,E2 induced gene 1 protein,E2-induced gene 1 protein,E2IG1,H11,Heat shock 22kDa protein 8,Heat shock 27
- Anwendung:
- IHC
- Konzentration:
- 0.3 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human HSPB8
- Uniprot:
- Q9UJY1
- Synonyme:
- alpha-crystallin C chain;CMT2L;DHMN2;E2-induced gene 1 protein;E2IG1;H11;heat shock 22kDa protein 8;heat shock 27kDa protein 8;heat shock protein beta-8;HMN2;HMN2A;HSP22;protein kinase H11;small stress protein-like protein HSP22
- Weitere Details:
- The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
- Versandbedingungen:
- Blue Ice