BRCA1 Polyclonal Antibody

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£106.20

War £118.00

SKU:: E-AB-10188
Zusätzliche Namen:: BRCA 1,BRCA1,BRCA1 DNA repair associated,BRCA1/BRCA2 containing complex subunit 1,BRCA1/BRCA2-containing complex,BRCAI,BRCC 1,BRCC1,Breast Cancer 1,Breast Cancer 1 Early Onset,Breast and ovarian cancer susceptibility protein 1,Breast cance,subunit 1
Anwendung:: IHC
Konzentration:: 0.3 mg/ml
Aufreinigung:: Affinity Purified
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Host:: Rabbit
Reaktivitäten:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant protein of human BRCA1
Uniprot:: P38398
Synonyme:: BRCA1/BRCA2-containing complex, subunit 1;BRCAI;BRCC1;breast and ovarian cancer susceptibility protein 1;breast cancer 1, early onset;breast cancer type 1 susceptibility protein;BROVCA1;early onset breast cancer 1;Fanconi anemia, complementation group S;FANCS;IRIS;PNCA4;PPP1R53;protein phosphatase 1, regulatory subunit 53;PSCP;RING finger protein 53;RING-type E3 ubiquitin transferase BRCA1;RNF53
Weitere Details:: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Versandbedingungen:: Blue Ice