D-AB-10453L
IL-17A Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- D-AB-10453L
- Zusätzliche Namen:
- Cytotoxic T-lymphocyte-associated antigen,IL-17A,Interleukin-17A,IL-17,CTLA-8,Il17a,Cytotoxic T-lymphocyte-associated antigen 8,Ctla8,Il17,CTLA 8,Cytotoxic T lymphocyte associated antigen 8,Cytotoxic T lymphocyte associated protein 8,Cytotoxic T lymphocyte associated serine esterase 8,IL 17A,Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8),Interleukin 17A,Interleukin17,Interleukin17A,OTTHUMP00000016597,OTTMUSP00000046003
- Anwendung:
- IHC
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Rat IL-17A protein expressed by E.coli
- Uniprot:
- Q61453
- Synonyme:
- Cytotoxic T-lymphocyte-associated antigen 8
- Weitere Details:
- IL17A,also named as IL-17,is a proinflammatory cytokine. IL-17,synthesized only by memory T cells and natural killer cells,has pleiotropic effects,mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein,that is widely expressed on epithelial cells,fibroblasts,B and T cells,and monocytic cells. In psoriatic skin lesions,both Th17 cells and their downstream effector molecules,e.g. IL-17 and IL-22,are highly increased.
- Versandbedingungen:
- Blue Ice