D-AB-10443L
BAFFR/TNFRSF13C Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- D-AB-10443L
- Zusätzliche Namen:
- B-cell-activating factor receptor,BAFF receptor (BAFF-R),BAFFR,BLyS receptor 3,BR3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human BAFFR/TNFRSF13C protein expressed by Mammalian
- Uniprot:
- Q96RJ3
- Synonyme:
- B cell-activating factor receptor;B-cell-activating factor receptor;BAFF receptor;BAFF-R;BAFFR;BLyS receptor 3;BROMIX;CD268;CVID4;prolixin;tumor necrosis factor receptor superfamily member 13C
- Weitere Details:
- Tumor necrosis factor receptor superfamily,member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen,is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen,lymph node and resting B cells. It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly,A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells,suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.
- Versandbedingungen:
- Blue Ice