D-AB-10240L
AMACR Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- D-AB-10240L
- Zusätzliche Namen:
- 2-methylacyl-CoA racemase, AMACR, AMACRD, Alpha methylacyl CoA racemase, Alpha-methylacyl-CoA racemase, Amacr, Macr1, RACE, RM,2 methylacyl CoA racemase
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse Amacr protein expressed by E.coli
- Uniprot:
- O09174
- Synonyme:
- 2-arylpropionyl-CoA epimerase;2-methylacyl-CoA racemase;alpha-methylacyl-CoA racemase;alpha-methylacyl-Coenzyme A racemase;Mac;Macr1
- Weitere Details:
- AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer (PCa). However,AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa,suggesting a hormone-dependent expression of AMACR. It has 3 isoforms produced by alternative splicing. Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) and congenital bile acid synthesis defect type 4 (CBAS4).
- Versandbedingungen:
- Blue Ice