D-AB-10103L
HTRA1 Polyclonal Antibody
Größe
£120.60
War £134.00
- SKU:
- D-AB-10103L
- Zusätzliche Namen:
- High-temperature requirement A serine peptidase 1, L56, PRSS11, Serine protease 11,Serine protease HTRA1
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human HTRA1 protein expressed by E.coli
- Uniprot:
- Q92743
- Synonyme:
- ARMD7;CADASIL2;CARASIL;high-temperature requirement A serine peptidase 1;HtrA;IGFBP5-protease;L56;ORF480;protease, serine, 11 (IGF binding);PRSS11;Serine protease 11;serine protease HTRA1
- Weitere Details:
- Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
- Versandbedingungen:
- Blue Ice