CQM003
CellaQuant[TM] Mouse IL-1B Beta (Interleukin 1 Beta) ELISA Kit
Größe
£128.70
War £143.00
- SKU:
- CQM003
- Zusätzliche Namen:
- Catabolin,IL1 beta,IL-1 beta,IL-1,IL1B,IL-1b,IL1-BETA,IL-1F2,IL1F2IL-1 beta,interleukin-1 beta,preinterleukin 1 beta,pro-interleukin-1-beta
- Anwendung:
- ELISA
- Physischer Zustand:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Spezies-Reaktivität:
- Mouse
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Reaktivitäten:
- Mouse
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P10749
- Synonyme:
- IL-;IL-1 beta;Il-1b;IL-1beta;interleukin-1 beta
- Weitere Details:
- Interleukin-1B Beta (IL-1B Beta) is a potent master pro-inflammatory cytokine. Synthesized as an inactive precursor, its maturation is tightly regulated, primarily by caspase-1 via inflammasome activation or directly by microbial proteases. Active IL-1B Beta is released through non-classical pathways like Gasdermin-D pores. It drives systemic inflammation, fever, immune activation (including Th17 differentiation), and angiogenesis, playing a central role in host defense. However, its activity is strictly controlled by natural inhibitors like IL-1 receptor antagonist (IL-1ra) and decoy receptors. Dysregulated or excessive IL-1B Beta production is a key pathogenic driver in numerous diseases, including rheumatoid arthritis, atherosclerosis, and diabetes, making it a critical therapeutic target.
- Versandbedingungen:
- Blue Ice