CellaQuant[TM] Human IL-1B Beta (Interleukin 1 Beta) ELISA Kit

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£128.70

War £143.00

SKU:: CQH015
Zusätzliche Namen:: Catabolin,IL1 beta,IL-1 beta,IL-1,IL1B,IL-1b,IL1-BETA,IL-1F2,IL1F2IL-1 beta,interleukin-1 beta,preinterleukin 1 beta,pro-interleukin-1-beta
Anwendung:: ELISA
Physischer Zustand:: Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
Spezies-Reaktivität:: Human
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Reaktivitäten:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P01584
Synonyme:: catabolin;IL-1;IL-1 beta;IL1-BETA;IL1beta;IL1F2;interleukin 1beta;interleukin-1 beta;preinterleukin 1 beta;pro-interleukin-1-beta
Weitere Details:: Interleukin-1B Beta (IL-1B Beta) is a potent master pro-inflammatory cytokine. Synthesized as an inactive precursor, its maturation is tightly regulated, primarily by caspase-1 via inflammasome activation or directly by microbial proteases. Active IL-1B Beta is released through non-classical pathways like Gasdermin-D pores. It drives systemic inflammation, fever, immune activation (including Th17 differentiation), and angiogenesis, playing a central role in host defense. However, its activity is strictly controlled by natural inhibitors like IL-1 receptor antagonist (IL-1ra) and decoy receptors. Dysregulated or excessive IL-1B Beta production is a key pathogenic driver in numerous diseases, including rheumatoid arthritis, atherosclerosis, and diabetes, making it a critical therapeutic target.