CQH012
CellaQuant[TM] Human IL-5 (Interleukin 5) ELISA Kit
Größe
£120.60
War £134.00
- SKU:
- CQH012
- Zusätzliche Namen:
- B-cell differentiation factor I,BCGFII,EDF,Eo-CSF,Eosinophil differentiation factor,IL5,IL-5,IL-5T-cell replacing factor,interleukin-5,TRF,TRFB cell differentiation factor I
- Anwendung:
- ELISA
- Physischer Zustand:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Reaktivitäten:
- Human
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P05113
- Synonyme:
- B-cell differentiation factor I;colony-stimulating factor, eosinophil;EDF;eosinophil differentiation factor;IL-5;interleukin-5;T-cell replacing factor;TRF
- Weitere Details:
- Interleukin-5 (IL-5) is a homodimeric cytokine, where two identical 126-amino-acid monomers are linked by a disulfide bond. It is primarily secreted by activated Th2 cells, with additional sources including eosinophils, mast cells, iNKT cells, and NK cells.IL-5 is the principal regulator of eosinophils, driving their differentiation, survival, activation, and chemotaxis. It also activates basophils. Beyond granulocytes, IL-5 acts on B cells to promote immunoglobulin production, growth, and differentiation, linking it to humoral immunity.Its biological effects are mediated by a cell surface receptor complex composed of a unique IL-5RA Alpha chain and the common beta chain (B Betac/CD131). Receptor engagement activates JAK2 and other kinases, triggering downstream JAK-STAT5 and RAS-MAPK signaling pathways. Bioavailability is naturally regulated by soluble IL-5RA Alpha, which acts as a decoy receptor.Thus, IL-5 is a central cytokine in type 2 immunity, allergic inflammation, and antibody responses, making it a key therapeutic target for eosinophil-driven diseases.
- Versandbedingungen:
- Blue Ice