CQH007
CellaQuant[TM] Human IL-18 (Interleukin 18) ELISA Kit
Größe
£128.70
War £143.00
- SKU:
- CQH007
- Zusätzliche Namen:
- IFN-gamma-inducing factor,IGIF,IGIFIL-1 gamma,IL18,IL-18,IL-1F4,IL-1g,Interferon gamma-inducing factor,Interleukin-1 gamma,interleukin-18
- Anwendung:
- ELISA
- Physischer Zustand:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Reaktivitäten:
- Human
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q14116
- Synonyme:
- iboctadekin;IFN-gamma-inducing factor;IGIF;IL-1 gamma;IL-18;IL-1g;IL1F4;Interferon gamma-inducing factor;interleukin 18 (interferon-gamma-inducing factor);interleukin-1 gamma;interleukin-18
- Weitere Details:
- Interleukin-18 (IL-18), originally termed interferon-gamma-inducing factor, is a key pro-inflammatory cytokine of the IL-1 family. Synthesized as an inactive precursor, its maturation requires cleavage by caspase-1, and it is released during pyroptosis via GSDMD pores, linking it to innate immune danger signals. Mature IL-18 signals through a receptor complex (IL-18R1/IL-18RAP), activating a MyD88/NF-K KappaB pathway that drives inflammatory gene expression. Its most critical function is the potent synergy with IL-12 to induce high-level interferon-gamma (IFN-G Gamma) production from T-helper 1 (Th1) cells and natural killer (NK) cells, defining its central role in Th1-type immunity. IL-18 also enhances NK cell cytotoxicity and regulates other cytokines like GM-CSF and IL-10. While promoting Th1 responses, it can also influence Th2 differentiation under specific conditions. Due to this potent activity, dysregulated IL-18 is implicated in autoimmune diseases (e.g., inflammatory bowel disease, psoriasis), metabolic syndromes, sepsis, and cancer progression. Therefore, therapeutic neutralization of IL-18 is a promising strategy for treating inflammation-driven pathologies.
- Versandbedingungen:
- Blue Ice