AN302099L
Recombinant Phospho-Erk1/2(Thr202, Tyr204) Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN302099L
- Zusätzliche Namen:
- Erk1T202ph,Erk1Y204ph,Erk1T202ph/Y204ph
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Klon:
- A823
- Uniprot:
- P27361, P28482
- Synonyme:
- ERK;ERK-1;ERK-2;ERK1;ERK2;ERT1;ERT2;extracellular signal-regulated kinase 1;extracellular signal-regulated kinase 2;extracellular signal-related kinase 1;HS44KDAP;HUMKER1A;insulin-stimulated MAP2 kinase;MAP kinase 1;MAP kinase 2;MAP kinase isoform p42;MAP kinase isoform p44;MAPK 1;MAPK 2;MAPK2;microtubule-associated protein 2 kinase;mitogen-activated protein kinase 1;mitogen-activated protein kinase 2;mitogen-activated protein kinase 3;NS13;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;p44-ERK1;p44-MAPK;P44ERK1;P44MAPK;PRKM1;PRKM2;PRKM3;protein tyrosine kinase ERK2
- Weitere Details:
- The p44/42 MAPK (Erk1/2) signaling pathway can be activated in response to a diverse range of extracellular stimuli, including mitogens, growth factors, and cytokines, and research investigators consider it an important target in the diagnosis and treatment of cancer. Upon stimulation, a sequential three-part protein kinase cascade is initiated, consisting of a MAP kinase kinase kinase (MAPKKK or MAP3K), a MAP kinase kinase (MAPKK or MAP2K), and a MAP kinase (MAPK). Multiple p44/42 MAP3Ks have been identified, including members of the Raf family, as well as Mos and Tpl2/COT. MEK1 and MEK2 are the primary MAPKKs in this pathway. MEK1 and MEK2 activate p44 and p42 through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. Several downstream targets of p44/42 have been identified, including p90RSK and the transcription factor Elk-1. p44/42 are negatively regulated by a family of dual specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.
- Versandbedingungen:
- Blue Ice