AN302011L
Recombinant CIRBP Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN302011L
- Zusätzliche Namen:
- CIRBP,CIRP,A18HNRNP
- Anwendung:
- IHC, WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Klon:
- A731
- Uniprot:
- Q14011
- Synonyme:
- A18 hnRNP;CIRP;cold-inducible RNA-binding protein;glycine-rich RNA binding protein;Glycine-rich RNA-binding protein CIRP;testicular tissue protein Li 39
- Weitere Details:
- Cold-induced RNA-binding protein (CIRBP) is a 172-residue, multifunctional sensor protein that was first isolated as a protein induced in mouse fibroblasts cultured at 32C. Conversely, CIRBP expression decreases in cells or tissues subjected to increased temperature. The CIRBP protein is composed of an amino-terminal RNA-binding domain and a carboxyl-terminal, glycine-rich domain. Stressful stimuli, such as hypoxia, heat shock, osmotic shock, or oxidative conditions, lead to translocation of CIRBP from the nucleus to cytoplasmic stress granules through a mechanism involving CIRBP methylation-dependent nuclear export. CIRBP plays a role in regulating apoptosis and preserving the stemness of neural stem cells at moderately low temperatures. Research studies demonstrate that CIRBP contributes to the regulation of circadian rhythm through post-translational modulation of CLOCK expression.
- Versandbedingungen:
- Blue Ice