AN301989L
Recombinant APAF1 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301989L
- Zusätzliche Namen:
- KIAA,Apoptotic protease-activating factor,Apoptotic peptidase activating factor,CED,APAF1,APAF-1,CED4,APAF,APAF 1,Apoptotic peptidase activating factor 1,Apoptotic protease activating factor,Apoptotic protease activating factor 1,Apoptotic protease-activating factor 1,CED 4,KIAA0413
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Klon:
- A709
- Uniprot:
- O14727
- Synonyme:
- APAF-1;apoptotic protease-activating factor 1;CED4
- Weitere Details:
- Apoptotic protease activating factor 1 (Apaf-1), originally identified as the mammalian homolog of the C. elegans apoptotic regulatory protein CED-4, is an important signaling protein involved in the activation of caspase-9 during apoptosis. Cytosolic Apaf-1 forms a complex with caspase-9 in the presence of cytochrome c and dATP, ultimately leading to caspase-9 activation and subsequent activation of caspase-3. The protein contains an amino-terminal CARD domain, a central CED-4 homology domain, and multiple WD-40 repeats at the carboxy terminus. Several isoforms of Apaf-1 are expressed through alternative splicing generating a small insert following the CARD domain as well as an extra WD-40 repeat. Apaf-1 knock-out mice display widespread defects in apoptosis and resistance to a variety of apoptotic stimuli.
- Versandbedingungen:
- Blue Ice