AN301982L
Recombinant CD8 beta Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301982L
- Zusätzliche Namen:
- LYT,LEU,CD8B,CD8B1,LEU2,LY3,LYT3,P37,T-Cell Surface Glycoprotein CD8 Beta Chain,CD8,Lyt3
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Klon:
- A702
- Uniprot:
- P10966
- Synonyme:
- CD8 antigen, beta polypeptide 1 (p37);CD8B1;LEU2;LY3;LYT3;P37;T lymphocyte surface glycoprotein beta chain;T-cell surface glycoprotein CD8 beta chain
- Weitere Details:
- Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated A Alpha and B Beta subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8A Alpha interacts with the A Alpha3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the A Alpha chain recruits the tyrosine kinase Lck, which is essential for T cell activation.
- Versandbedingungen:
- Blue Ice