AN301939L
Recombinant SLC25A12 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301939L
- Zusätzliche Namen:
- AGC,EIEE,SLC25A,SLC25A12,AGC1,ARALAR,EIEE39,ARALAR1,Araceli hiperlarga,Calcium binding mitochondrial carrier superfamily member,Calcium binding mitochondrial carrier superfamily member Aralar1,Calcium-binding mitochondrial carrier protein Aralar1,CMC1,member 12,Mitochondrial aspartate glutamate carrier 1,solute carrier family 25,Solute carrier family 25 (aspartate/glutamate carrier) member 12,Solute carrier family 25 (mitochondrial carrier Aralar) member 12,Solute carrier family 25 member 12
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human SLC25A12 fragment
- Klon:
- A655
- Uniprot:
- O75746
- Synonyme:
- AGC1;araceli hiperlarga;ARALAR;calcium binding mitochondrial carrier superfamily member Aralar1;calcium-binding mitochondrial carrier protein Aralar1;DEE39;EIEE39;mitochondrial aspartate glutamate carrier 1;solute carrier family 25 (aspartate/glutamate carrier), member 12;solute carrier family 25 (mitochondrial carrier, Aralar), member 12;Solute carrier family 25 member 12
- Weitere Details:
- The calcium-binding mitochondrial carrier protein (SLC25A12), also named as ARALAR or AGC1, is an aspartate-glutamate exchange protein responsible for transporting mitochondrial aspartate across the mitochondrial inner membrane in exchange for cytosolic glutamate. SLC25A12 and other proteins of the aspartate-glutamate carrier (AGC) group are required for the transfer of mitochondrial aspartate to the cytosol, a key step in urea synthesis. Research studies using SLC25A12-knockout mice indicate that SLC25A12 plays an important role in proper CNS myelination. Mice lacking SLC25A12 suffer from hypomyelination as a result of a lack of oligodendrocyte maturation caused by decreased brain N-acetylaspartate levels. Mutation of the corresponding SLC25A12 gene can result in global cerebral hypomyelination and severe psychomotor retardation, caused by deficient SLC25A12 activity and limited mitochondrial aspartate efflux.
- Versandbedingungen:
- Blue Ice