AN301924L
Recombinant TBLR1/TBL1XR1 Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301924L
- Zusätzliche Namen:
- MRD,IRA,TBLR,TBL1XR,TBL1XR1,C21,DC42,IRA1,MRD41,TBLR1
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human TBLR1/TBL1XR1 fragment
- Klon:
- A640
- Uniprot:
- Q9BZK7
- Synonyme:
- C21;DC42;F-box-like/WD repeat-containing protein TBL1XR1;IRA1;MRD41;nuclear receptor co-repressor/HDAC3 complex subunit;nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1-related protein 1;TBLR1;transducin beta like 1 X-linked receptor 1;Transducin beta-like 1X-related protein 1
- Weitere Details:
- TBL1-related protein 1 (TBLR1/TBL1XR1) and Transducing B Beta-like protein 1 (TBL1X/TBL1) were originally identified as subunits of the co-repressor silencing mediator for retinoic and thyroid hormone receptor (SMRT) and nuclear receptor co-repressor (NCoR) complexes. These two factors are required for the exchange of co-repressor complexes for co-activators by acting as adaptors to recruit the ubiquitin/proteasome machinery that degrades the co-repressor proteins during ligand mediated activation of transcription. Co-factor exchange driven by TBLR1/TBL1XR1 and TBL1X/TBL1 appears to be the mechanism by which c-Jun and NF-K KappaB mediated transcription is activated and is therefore likely to be the mechanism employed by other signal-dependent transcription factors as well. In addition, both TBLR1/TBL1XR1 and TBL1X/TBL1 have essential roles in regulating the Wnt-signaling pathway by recruiting B Beta-catenin to Wnt target genes to activate transcription. Depletion of TBLR1/TBL1XR1 significantly inhibited Wnt-beta-catenin- induced gene expression and oncogenic growth in vitro and in vivo. Research studies have shown that upregulation of TBLR1/TBL1XR1 is observed in a variety of solid tumors, and is correlated with advanced tumor stage, metastasis and poor prognosis.
- Versandbedingungen:
- Blue Ice