AN301922L
Recombinant FEN1 Monoclonal Antibody
Größe
£252.90
War £281.00
- SKU:
- AN301922L
- Zusätzliche Namen:
- RAD,FEN,FEN1,FEN-1,MF1,RAD2
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human FEN1 fragment
- Klon:
- A638
- Uniprot:
- P39748
- Synonyme:
- DNase IV;FEN-1;flap endonuclease 1;Flap structure-specific endonuclease 1;Maturation factor 1;maturation factor-1;MF1;RAD2
- Weitere Details:
- Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double-stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.
- Versandbedingungen:
- Blue Ice