AN301897L
Recombinant SLC7A5/LAT1 Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301897L
- Zusätzliche Namen:
- LAT,MPE,hLAT,SLC7A,SLC7A5,4F2LC,CD98,D16S469E,E16,LAT1,MPE16,hLAT1,CD98LC
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human SLC7A5/LAT1 fragment
- Klon:
- A613
- Uniprot:
- Q01650
- Synonyme:
- 4F2 light chain;4F2LC;CD98;CD98 light chain;D16S469E;E16;integral membrane protein E16;L-type amino acid transporter 1;large neutral amino acids transporter small subunit 1;LAT1;MPE16;sodium-independent neutral amino acid transporter LAT1;solute carrier family 7 (amino acid transporter light chain, L system), member 5;solute carrier family 7 (cationic amino acid transporter, y+ system), member 5;Solute carrier family 7 member 5;y+ system cationic amino acid transporter
- Weitere Details:
- L-type amino acid transporter 1 (LAT1), also known as Solute carrier family 7 member 5 (SLC7A5), is a high-affinity neutral transporter of larger amino acids. It facilitates the cellular amino acid uptake in a sodium independent manner and selectively transports D-and L-isomers of small neutral amino acids. LAT1 also regulates amino acid exchange in conjunction with solute carrier family 1 member 5 (SLC1A5). Transport of thyroid hormones across the placenta is established via LAT1 during normal fetal development. LAT1 promotes neuronal cell proliferation by regulating the transport of amino acids across the blood brain barrier. LAT1 is upregulated in various cancer types including breast cancer, lung cancer, prostate cancer, and gliomas. High expression of LAT1 is detected in non-small cell lung cancer with lymph node metastases. Increased LAT1 expression is a novel biomarker of high-grade malignancy in prostate cancers. Inhibition of LAT1 suppresses tumor cell growth in several tumor types.
- Versandbedingungen:
- Blue Ice