AN301895L
Recombinant MAO-A Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301895L
- Zusätzliche Namen:
- MAOA,BRNRS,MAO-A
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human MAO-A fragment
- Klon:
- A611
- Uniprot:
- P21397
- Synonyme:
- amine oxidase [flavin-containing] A;BRNRS;MAO-A;monoamine oxidase type A
- Weitere Details:
- Monoamine oxidase A (MAO-A), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAO-A promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network. In addition, MAO-A expression in adipose tissue macrophages is upregulated in aging, leading to the reduction of noradrenaline availability in adipose tissue. Decreased levels of noradrenaline contribute to the aging-related decline of catecholamine-induced lipolysis in adipocytes. Furthermore, sympathetic neuron-associated macrophages import and degrade norepinephrine via the transporter SLC6A2 and MAO-A, respectively, and thus contribute to obesity.
- Versandbedingungen:
- Blue Ice