AN301815L
Recombinant CBX4 Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301815L
- Zusätzliche Namen:
- Cbx,CBX4
- Anwendung:
- IHC, WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human CBX4 fragment
- Klon:
- A527
- Uniprot:
- O00257
- Synonyme:
- chromobox homolog 4 (Pc class homolog, Drosophila);chromobox protein homolog 4;chromobox-like protein 4;E3 SUMO-protein ligase CBX4;NBP16;NS5ATP1-binding protein 16;Pc class 2 homolog;PC2;polycomb 2 homolog
- Weitere Details:
- CBX4 is a component of the PRC1 complex, which together with Ring1 strongly enhances the E3 ubiquitin ligase activity of the Ring2 catalytic subunit. CBX4 itself is a SUMO E3 ligase, and its function influences EMT, DNA damage response, tumor angiogenesis, and self-renewal. E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is involved in the SUMOylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression.
- Versandbedingungen:
- Blue Ice