AN301802L
Recombinant PHF8 Monoclonal Antibody
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£252.90
War £281.00
- SKU:
- AN301802L
- Zusätzliche Namen:
- ZNF,Phf,KIAA,KIAA1111,ZNF422,PHF8
- Anwendung:
- WB
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Protein A Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PHF8 fragment
- Klon:
- A514
- Uniprot:
- Q9UPP1
- Synonyme:
- [histone H3]-dimethyl-L-lysine(36) demethylase PHF8;[histone H3]-dimethyl-L-lysine(9) demethylase PHF8;histone lysine demethylase PHF8;JHDM1F;jumonji C domain-containing histone demethylase 1F;KDM7B;MRXSSD;PHD finger protein 8;ZNF422
- Weitere Details:
- PHF8 is a histone lysine demethylase that functions as a transcriptional activator by specifically demethylating a number of repressive histone methylation marks: mono- and Dimethyl-histone H3 Lys9 (H3K9me1 and H3K9me2), Dimethyl-histone H3 Lys27 (H3K27me2) and Monomethyl-histone H4 Lys20 (H4K20me1). PHF8 contains an N-terminal zinc finger-like PHD domain that binds Trimethylated histone H3 Lys4 (H3K4Me3) and a C-terminal jumonji domain that is responsible for the demethylase activity. PHF8 is highly expressed in prostate cancer, laryngeal squamous cell carcinoma, and human non-small-cell lung cancer (NSCLC). Its expression is predictive of poor survival. Overexpression of PHF8 increases cell proliferation and cell motility, while silencing of PHF8 reduces cell proliferation, migration, and invasion.
- Versandbedingungen:
- Blue Ice